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Niementowski quinoline synthesis : ウィキペディア英語版 | Niementowski quinoline synthesis
The Niementowski quinoline synthesis is the chemical reaction of anthranilic acids and ketones (or aldehydes) to form γ-hydroxyquinoline derivatives. ==Overview== In 1984, Niementowski reported that 2-phenyl-4-hydroxyquinoline was formed when anthranilic acid and acetophenone were heated to 120–130 °C. He later found that at higher heat, 200 °C, anthranilic acid and heptaldehyde formed minimal yields of 4-hydroxy-3-pentaquinoline.〔Hartz, pp. 376–384〕 Several reviews have been published.
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